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Drug Repurposing Encyclopedia

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Drug-prioritization Tau score: The value of drug-prioritization Tau score represents a standardized score, ranging from -100 to 100, to measure the specificity of an association between a particular drug and a signature. A highly positive Tau (e.g. Tau = 99) of a drug-signature association suggests that only 1% of the reference signatures showed higher association compared to the current signature.

On the DRE platform, associations with absolute Tau > 80 are shown for each drug-signature. The effect category of an association is based on the sign of Tau score. A positive Tau score indicates that the drug will boost the gene signature and a negative Tau score shows the drug will suppress the gene signature. To draft a quick understanding of each molecular signature and drug, reference links to the drug and signatures, as well as the descriptions for the signatures are provided in all result tables.

Drug-Repurposing module allows users to query for top-associated drugs (abs(Tau) > 80 and FDR < 0.01) for a selected disease. Results are visualized in a form of interactive plot and table. Threshold can be adjusted by the user in the table to facilitate any further filtering. There are currently 9 disease categories in the module, namely,

To help with navigation and understanding of the interface, illustrations of the interface are shown below:

Below is a quick walkthrough on one of the disease categories:

Drug-Pathway module allows users to query significant pathways (abs(Tau) > 80 and FDR < 0.01) associated with a selected drug. Results are visualized in a form of interactive plot and table. Threshold can be adjusted by the user in the table to facilitate any further filtering. The query also allows users to quickly visualize functional enrichment of a drug with a particular pathway of interest, in a form of interactive gene set enrichment plot and table. There are currently two sub-panels, namely pathway and drug, in the module available for query. The pathway panel enables an interactive exploration of the top drugs associated with each pathway category from the MSigDB. As for the drug panel, top associated pathway signatures will be shown.

To help with navigation and understanding of the interface, illustrations of the interface are shown below:

1. Pathway panel:

For the Query Table:

2. Drug panel:

Below is a quick walkthrough of the panel:

DRE Analysis Platform consists of a series of analysis to mediate users during the process of drug repurposing. There are currently four tools available on DRE to carry out the following analyses:

Below is are quick walkthroughs of the analyses subsequently:

Drug-Repurposing

Gene Set Enrichment (GSEA)

Gene Set Similarity

We Integrate Drug Profiles with Disease Signatures

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